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AOD 9604, HGH Fragment 176-191, and 5-Amino-1MQ operate through entirely different pathways and lack the large-scale RCT data supporting the GLP-1 class

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In preclinical rat models of STZ-induced DN, PW507 demonstrated significant efficacy in alleviating mechanical allodynia and thermal hyperalgesia following acute and chronic (2-week) administration without inducing tolerance and visual evidence of toxicity