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[DOI] [PMC free article] [PubMed] [Google Scholar] 454.Shimizu M, et al

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Microbiota dysbiosis, such as changes in the structure, quantity, and variety of bacteria, increases the susceptibility of the host to infection by various pathogens, exacerbates gut and brain autoimmunity and inflammation, induces diverse methods of metabolic disorders, and fosters the progression of neurological diseases

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Rats in the LPS + NAC group received NAC by i.v

1 Introduction Globally, knee osteoarthritis (KOA) is one of the most commonly occurring disabling conditions, affecting over 364 million adults (Li et al., 2024), and it is widely recognized as the most prevalent and representative form of osteoarthritis (OA)