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Alzheimer and Parkinson diseases, frontotemporal lobar degeneration and amyotrophic lateral sclerosis overlapping neuropathology start in the first two decades of life in pollution exposed urbanites and brain ultrafine particulate matter and industrial nanoparticles, including Fe, Ti, Al, V, Ni, Hg, Co, Cu, Zn, Ag, Pt, Ce, La, Pr and W are key players

The cell danger response (CDR) is a chronic stress response that occurs on a cellular level involving the mitochondria

So it may be that the liver has to work extra hard to detoxify the body when its low 0on B12, even when there's no liver damage

Curr Nutr Rep

This is where the gap between injections and oral supplements becomes significant

Martel CL, Mackic JB, Matsubara E, Governale S, Miguel C, Miao W et al (1997) Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimers amyloid beta