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Note that Carnitine comes in two versions, the inactive D-isomer and the biological active L-isomer

Free heme is assigned many toxic actions, such as being a pro-oxidant [21,22,211], pro-inflammatory [212,213] and vaso-occlussive agent [214,215] that causes the depletion of NO [216] and oxidation of serum lipoproteins (atheromatosis) [21]

Reviews in Endocrine and Metabolic Disorders 19, 293300

Rats were exposed with four cigarettes per day for 6 weeks

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(i) Specific affected brain areas (04) (score 0 indicates no histopathologic change), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) were assessed as follows: small, patchy, complete or incomplete infarcts (10% of area affected) (score 1)