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The molecular spectrum of amyloid-beta (A) in neurodegenerative diseases beyond Alzheimers disease

This widespread microvascular starvation exacerbates the deep tissue fatigue, muscle pain, and cognitive impairments frequently reported by patients

L., Schneweis, D

Abstract In plants, exposure to temperature extremes, heavy metal-contaminated soils, drought, air pollutants, and pathogens results in the generation of reactive oxygen species that alter the intracellular redox environment, which in turn influences signaling pathways and cell fate

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In vivo, emodin and tetrahydropalmatine synergistically reduces colon cancer (HT-29) tumor size, increasing F4/80 expression, decreasing IL-6 and TGF- levels, promoting tumor oxidation, and down-regulating p53 and STAT3 protein expression