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doi: 10.1271/bbb.59.236

The graduated escalation schedule minimizes these risks

doi:10.1007/s00415-019-09282-4 Heckmann JG, Urban PP, Pitz S, Guntinas-Lichius O, Ggyor I

Studies where GF rodents have been recolonized with normal microbiota (i.e., from specific pathogen-free animals) at different ages have shown that post-weaning re-colonization is more effective at restoring GF deficits than re-colonization later in life, at least for specific aspects of brain or immune function and behavior 5256

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For further information regarding WADAs approach to the routes of administration of glucocorticoids and washout periods, please refer to the Summary of Major Modifications and Explanatory Note