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Barbato G, Cicero DO, Nardi MC et al (1999) The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism

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Inflammation is closely linked to oxidative stress and cancer

The consistent clinical failure of agents targeting a single mode of cell death provides compelling clinical validation for the mechanistic principle outlined in Section 2.4.2: MIRI triggers an interconnected web of cell death programs, suggesting future strategies may need to be multi-modal or target more upstream events