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BPS exposure for 120 days decreased IPL and GCL thickness, increased thickness of the RPE and changed expression of opsin genes 41

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Cells with genetic predispositions, such as those with mutations in the MC1R gene or lower melanin levels, exhibit impaired DNA repair mechanisms, increasing their susceptibility to melanoma development 54

Key molecular features include the F23 Cagri residue anchoring the peptide at the receptor transmembrane (TM) bundle level and the micelle, an E14-R17 intramolecular salt bridge enhancing helical stability, and C-terminal P37 Cagri interaction with the receptor ECD

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