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Similarly, in a recent large population-based cohort of T2DM patients, long-term use of NAC was associated with a significantly lower risk of MACE, with the effect increasing in magnitude at higher cumulative doses [180]

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In an evaluation of protein oxidation detected using a fluorescent probe targeted to sulfenic acid (DCP-Rho1) applied to cells activated with the lipid growth signal lysophosphatidic acid (LPA), our group recently found evidence for enhanced protein oxidation around redoxosomes (ROS-generating, signaling endosomes) which were also enriched in internalized LPA receptors [134]