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Your circadian rhythm can be interrupted for other reasons besides travel and shift work: Artificial lights (delay melatonin release) Ambient temperature (too hot or too cold) Eating before 8 am or after 6 pm (core temperature increases during digestion) Exercising too close to bedtime (core temperature too hot) Alcohol (reduces melatonin) Caffeine (delays melatonin release) Melatonin release is necessary for sleep and its production is dependent on both the lack of light and the ability of the body to lower its core body temperature

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J Clin Endocrinol Metab 87 : 35373542 Puder JJ et al

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Increased Muscle Mass Improved Fat Loss Enhanced Recovery Increased Energy Levels What Is CJC-1295

In cortical neurons subjected to hypoxia/reoxygenation, HGF protects from apoptosis via the ERK pathway and, at a lesser extent, the PI-3K/AKT pathway (He et al., 2008)