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Moreover, they figured out that heme oxygenase-1 (HMOX1) was the major culprit for iron release in DOX-induced cardiotoxicity and provided intriguing insights for the first time into the role of ferroptosis in cardiac cell death linked to cardiomyopathy [19, 106]

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doi: 10.1136/thorax.55.4.266

Heat exposure above 50C generally denatures the proteins