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Together, these mechanisms show that mitochondrial zinc homeostasis is a dynamic, tightly regulated process integrating zinc transport, enzymatic metallation, redox control and metabolic sensing, forming the molecular foundation through which zinc supports mitochondrial structure and function

Docosahexaenoic acid

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Overall, DMSA therapy in this study seemed relatively safe, with only a few reports of adverse effects that were generally temporary and of mild or moderate severity

Collectively, these results show that inhibiting both GGCT and xCT together effectively blocks the supply of intracellular cysteine, thereby inducing ferroptosis via GSH depletion and redox collapse, which in turn suppresses glioblastoma cell proliferation (Fig