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The organic layer was separated, concentrated in vacuo, re-dissolved in methanol and analyzed by LCMS

L-lactate is processed predominantly in the liver and heart through L-lactate dehydrogenase (LDH), whereas D-lactate metabolism occurs via D-2-hydroxyacid dehydrogenase, an enzyme present in fewer tissues with a different regulatory mechanism ( Once exclusively considered a metabolic waste by-product, lactic acid is now acknowledged as a pleiotropic signal involved in diverse physiological and pathological conditions ( L-lactate is a naturally occurring enantiomer in mammals ( The etiology of D-lactic acidosis in bovines is often due to disruptions in digestive fermentation caused by excessive grain and carbohydrate intake, or infectious diarrhea, commonly observed in neonatal calves ( Although the role of L-lactate in exercise, hypoxia, and metabolic diseases has been extensively studied, the physiological and pathophysiological roles of D-lactate remain poorly understood

Hamblin, M

[DOI] [PubMed] [Google Scholar] Kretzschmar M., Mller D., Hbscher J., Marin E., Klinger W

of Drug Del

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