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doi: 10.1056/NEJMoa1803484 65 Penn-NicholsonAGeldenhuysHBurnyWvan der MostRDayCLJongertEet al

SAMe is synthesized in the first reaction of the methionine cycle through the action of methionine adenosyltransferase (MAT), which uses methionine and ATP 6

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In hippocampal neurons exposed to the oxygenglucose deprivation and reoxygenation (OGD/R) model, propofol (0.150 M) restricted excessive mitochondrial fission by inhibiting dynamin-related protein 1 (Drp1) and fission protein 1 (Fis1) binding
