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Absorbance of the supernatants was measured at 540 nm

Although Compounds 1.62 and 1.63 lost the efficacy for a major detoxification process of GSH by being unable to interact with the GST enzyme, this does not indicate a loss for all the detoxification pathways

Peripheral blood neutrophil death in patients and SLE-prone mice could be inhibited by classical ferroptosis inhibitors, liproxstatin-1, and deferoxamine, while necroptosis and apoptosis inhibitors had relatively less effect on neutrophils, confirming that ferroptosis is the predominant neutrophil death pathway in SLE patients

But some recent studies have not shown any beneficial effect of antioxidant therapy

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Author Contributions Conceptualization, formal analysis, investigation, methodology, and writingoriginal draft, F.G