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2021 Nov 17;13(22) PMCID: PMC8616238
The metabolites lactate and fumarate are also regulators of GSH synthesis
Can help modulate oxidative stress signaling and reduce reactive-burden markers in experimental settings
These changes are also related to improvements in quality of life, as they can alleviate common symptoms such as fatigue, jaundice, and gastrointestinal discomfort in patients with advanced liver disease [44]
These pathways are mediated through the secondary rise of Insulin-like Growth Factor 1 (IGF-1), which acts as a primary anabolic messenger in musculoskeletal tissues
Onaolapo et al., 2016b)
