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DALYs and mortality related to obesity are the consequence of the multiple comorbidities spanning from cardiovascular (CV) and metabolic diseases, such as heart failure (HF) and type 2 diabetes (T2D), to many cancers, infertility and respiratory (e.g., obstructive apnea syndrome), cutaneous (e.g

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Beta-arrestin-dependent spontaneous alpha1a-adrenoceptor endocytosis causes intracellular transportation of alpha-blockers via recycling compartments