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doi: 10.3390/ijms21155338 37 GramegnaA.AmatiF.TerranovaL.SotgiuG.TarsiaP.MigliettaD.et al

Shimizu N, Hamada Y, Morozumi R, Yamamoto J, Iwai S, Sugiyama KI, Ide H, Tsuda M (2023) Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding

By contrast, a 6-month-long human study utilizing dosages of 250 or 1,000 mg/day led to significant increases in body stores of GSH in a dose- and time-dependent manner when the possible differences in erythrocyte volume and number, which significantly influence GSH levels, were taken into consideration 20

There is a very strong body of experimental evidence indicating a neuroprotective role of UA, mediated through anti-inflammatory and antioxidative mechanisms that themselves are likely to be closely interrelated (summarised in Fig

Transcriptional regulation of GSH synthesis Tumor cells also engage complex transcriptional programs to preserve GSH homeostasis under cuproptotic stress

[DOI] [Google Scholar] 112.Kempka A.P., Lipke N.L., Da Luz Fontoura Pinheiro T., Menoncin S., Treichel H., Freire D.M.G., Di Luccio M., De Oliveira D