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The injection is given in the upper arm (deltoid muscle) as an intramuscular injection

The prominence of hydrophobicity-related descriptors and normalized van der Waals volume terms is consistent with current understanding of BBB-relevant peptide properties, in which penetration is shaped by a constrained balance of polarity, compactness, residue packing, and surface chemistry ( Several limitations should be acknowledged

21 Comparative trials favor long acting agents (exenatide once weekly, liraglutide, dulaglutide, semaglutide) over short acting agents (exenatide twice daily and lixisenatide) in providing superior glycemic control

Bokov AF, Garg N, Ikeno Y, Thakur S, Musi N, DeFronzo RA, Zhang N, Erickson RC, Gelfond J, Hubbard GB, Adamo ML, Richardson A

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Adding more bacteriostatic water lowers the concentration and makes injections significantly more tolerable