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The main rationale for cycling rather than continuous use involves conservative safety practices given limited long-term human data, cost management, and theoretical concerns about receptor desensitization with extended exposure

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In complementary studies, they further demonstrate that methanobactin therapy, a bacteria-derived chalkophore with high copper affinity, restores intestinal barrier integrity, improves mitochondrial ultrastructure, and reduces inflammatory changes in WD animal models and ATP7B-deficient human enterocytes [9]