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Conversely, the loss of charge can diminish solubility in aqueous buffers, potentially requiring organic co-solvents (e.g., acetonitrile) for reconstitution

Similarly to the data obtained in animals, several studies have reported that also in human subjects the concentration of GSH declines with aging [47,48,49,50,51,52]

3 Results In this study, we aimed to determine if three drugs from the SSRI family (sertraline, fluoxetine, and citalopram), commonly used as antidepressants (Figure 1, right panel), can be repurposed as inhibitors of MRP1 and MRP7 transporters (Figure 1, left panel) to overcome MDR in cancer cells

10.1074/jbc.M111.335174 217 UrsiniF.MaiorinoM

This is because glutathione enhances mitochondrial functionthe energy powerhouse of cells