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Conclusions The concept of the leaky gut, although used to explain the pathogenesis of many common diseases, should be rethought in terms of the available data that support the many means by which luminal substances cross the gut mucosal barrier

Owing to its location adjacent to the glomeruli and the presence of specific organic acid-base secretion systems, the proximal tubule is often exposed to higher concentrations of toxins compared to other nephron segments, making it the primary site of nephrotoxic damage [ 43 ]

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