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184 Overall, natural and synthetic SIRT1 activators rely on SIRT1s multi-dimensional roles in metabolism, inflammation, and oxidative stress regulation in MASLD, as shown in Table 1

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Patients present with onset of sideroblastic anemia at adolescence, lactic acidemia, and muscle weakness

Exercise can promote the metabolism of tryptophan in muscles, enhancing the generation of kynurenine, which plays an vital role in regulating immune responses and energy homeostasis (Martin et al., 2020)