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Kim K, Yang WH, Jung YS, et al

Key mitochondrial proteins targeted for UPS-mediated degradation include mitochondrial precursors essential for OXPHOS 15,16 , and those involved in maintaining organelle morphology 15,16

Describe and interpret the abnormalities in the biochemistry

Impaired mitochondrial fusion and enhanced mitochondrial fission have been reported in mice with Mfn2 gene knockout, which was accompanied by metabolic disorders such as glucose intolerance, enhanced hepatic gluconeogenesis, and leptin resistance (66, 103)

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