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It is known that they interact with transcriptional repressor factors, exerting a negative regulatory effect on transcriptional activation of NRF2

Additionally, in the eye ascorbate-derived L-erythrulose gives rise 3-deoxythreosone, a reactive osone that glycates lens proteins [103], [104] and C5 aldonic acids which may be converted to D-xylulose 5-P and enter central metabolism via the pentose phosphate pathway [64], [105], [106]

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E., Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases, Physiological Reviews 94, no

They often appear on the face, chest, and hands