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In addition to its participation in the WWC, ascorbate is also required for the regeneration of lipid-soluble antioxidants, particularly tocopherols and tocotrienols (vitamin E), which protect the polyunsaturated fatty acids in the thylakoid membranes from oxidation to chromanoxyl radicals by singlet oxygen

doi: 10.1016/j.jbc.2022.102778

From Aggregation-Induced Emission of Au(I)Thiolate Complexes to Ultrabright Au(0)@Au(I)Thiolate CoreShell Nanoclusters

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Even at low plasma concentrations, the highly reactive thiol group on the NAC molecule breaks down oxidized cystine circulating in the blood, liberating free L-cysteine

Elevated ROS level in tumor cells has also been implicated in EMT which played critical role in PD-L1 expression in neoplastic cells [7880]