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B-12 shots SQ at 6 mg per day best given in daytime

Clin Exp Immunol 206:314324

(c) it is a mutagen in a number of microbial systems, but there is no evidence of its mutagenicity in mammals, in which it is rapidly degraded

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doi: 10.1016/j.neuroscience.2016.07.020, 87

Yet, most remain at proof-of-concept or early preclinical stages, with limited scalability, regulatory clarity, and long-term safety validation
