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Nygrd O, Refsum H, Ueland PM, and Vollset SE (1998)

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The structure of the complex shows that the enzyme uses several highly conserved residues, e.g., D179, H413, N489, W619, N636, and K638, to form hydrogen bonds and electrostatic interactions with the glucuronic acid moiety of the substrate

Funding The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: the grant (01.13.0315.00 - DendePalm Project) for this study was awarded by the Brazilian Ministry of Science, Technology, and Innovation (MCTI) via the Brazilian Research and Innovation Agency (FINEP)

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Alpha-1 antitrypsin deficiency: Current perspective from genetics to diagnosis and therapeutic approaches