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One such piece of research is a 2020 review published in the journal Nutrients (1)

The typical components include: Vitamin B12 (cobalamin): An essential water-soluble vitamin crucial for red blood cell formation, neurological function, and DNA synthesis

even minor impurities can lead to skewed data

This is often due to: Slower metabolic rate Reduced growth hormone levels Insulin resistance Increased stress and inflammation Lower energy production The body becomes less efficient at burning fat and more efficient at storing it

Storage Store at 4C in a dry, sterile, light-protected environment

Because recent evidence shows little benefit on cardiovascular outcomes from adding extended-release niacin to statin therapy, or from raising HDL-cholesterol levels, niacin is no longer considered standard of care for reducing cardiovascular risk