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Aging: Naturally, our bodies become less efficient at producing antioxidants as we get older

doi: 10.1016/j.freeradbiomed.2003.12.014

The energy of this process, in which electrons are transferred from the substrates of the TCA to oxygen, is coupled to vectorial transport of H + from the mitochondrial matrix space [22]

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The chronic high glucose condition is a hallmark of diabetes-related pathogenesis, and has been demonstrated to impair the osteogenic differentiation of periodontal ligament stem cells (PDLSCs), leading to delayed recovery of periodontal defects in diabetic patients