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Think of actin as the cellular scaffolding
And while its best known as a reproductive hormone, estrogen also plays a key role in maintaining joint health, in part because it helps regulate collagen production
Thats obviously a much more extreme type of stress
[DOI] [PMC free article] [PubMed] [Google Scholar] Kirkham 2010 Kirkham JJ, Dwan KM, Altman DG, Gamble C, Dodd S, Smyth R, et al

The MET gene is activated by point mutations in small-cell lung cancer (SCLC) and renal papillary carcinomas

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