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IS: PGA 13 C 5 was obtained from MedChemExpress (Monmouth Junction, NJ, USA)

AKI, Acute Kidney Injury
EMT-TFs include SNAIL, slug, zinc finger E-box binding homeobox (ZEB) 1, ZEB2, Twist1, Twist2, E47, and Tcf 3

To explore the PK and effect of multiple doses on safety-related endpoints and plasma lipids and biomarkers, another 50 healthy individuals were randomized into a multiple-ascending dose (MAD) trial (Fig

Table 4 Relevant indicators of the study sample

Serotonergic mechanisms regulating the GI tract: experimental evidence and therapeutic relevance
