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Neutrophils are normally recruited by chemokines released by tumors, and tumor-associated neutrophils (TANs) promote CD8 + T cells responses and anti-tumor activity in the absence of tumor-derived TGF-, whereas in the presence of TGF- promotes the tumor-promoting activity of CD8 + T cells [104]

Another limitation is that information on potential confounding factors (such as diet, weight, and medication) was not examined

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In malignant tumors, IFN produced by CD8+ T cells increases with rising Gln concentrations, indicating that immunotherapy targeting tumors also relies on Gln-dependent activation of CD8+ T cells (12)