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doi: 10.1172/jci.insight.174220 115 LiKWuJLQinBFanZTangQLuWet al

Among the multiple biological activities of astaxanthin, its antioxidant, anti-obesity, and muscle-related effects were selected as the main focus of this review because these domains are mechanistically interconnected through oxidative stress regulation, mitochondrial bioenergetics, and energy homeostasis, and are the most consistently supported by preclinical and clinical evidence

Of these must-haves, only four are fat-soluble, meaning the body can store them within the fat cells when taken and/or consumed in excess

This expansion leads to FMR1 promoter silencing via an epigenetic mechanism involving DNA methylation of the CGG repeat region and adjacent regulatory areas (216)

Exogenous factors can also generate oxidants, including radiation and sunlight exposure (via singlet oxygen, 1 O 2 , formation), metal ions, and environmental pollutants (e.g., chemicals, drugs, solvents, particulates, cigarette smoke)