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Moreover, DMDD exerts a dose-dependent effect on the expression of Hif3a, Bad, Bax, caspase 9, cleaved caspase 9 (37 kDa), and cleaved caspase 3 (Figure 8C)

Spatial imaging (Figure a) revealed the localized accumulation of cardenolides like calotoxin ( m / z 587.2250, [M+K] + , red) exclusively in the injured areas, while dihydroxyflavone ( m / z 253.2639, [M+H] + , green) were uniformly distributed on the entire leaf surface

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The Ycf1 R-domain is in a phosphorylated state with an ordered regulatory domain The most striking findings of our structures are the visualization of every regulatory element, including the R-domain (residues 901-935) phosphorylated in three positions