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The up-regulation of EGF coupled with loss of cell cycle control (both p16 INK4A and p14 ARF ) was shown to induce higher-grade glioma formation in vivo

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In fact, transient overexpression of EAAT3 in hippocampal HT22 cells led to increased intracellular GSH levels in the presence of high glutamate concentrations, offering protection against oxidative glutamate toxicity [44, 45]

Sies H, Belousov VV, Chandel NS et al (2022) Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Matsuyama T, Yoshinaga SK, Shibue K, Mak TW

10.1503/jpn.200159 J Psychiatry Neurosci
