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Concomitant administration of valproate and cannabidiol has been associated with an increased risk of ALT and/or AST elevation

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We verified the hypothesis that CHK2 might regulate hydroxylation-dependent proteasomal degradation of HIF-1 because proline hydroxylation is a chief regulator of HIF-1 protein concentrations

Nat Commun 11: 395, 2020

In breast cancer, particularly in TNBC, HIF-1 binds to the VEGF promoter directly and activates VEGF transcription (115)