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Tobacco smoking and liver cancer risk: potential avenues for carcinogenesis

Practically speaking, if you weigh significantly more than the trial average, you may find that: The 2.5 mg initiation dose produces minimal noticeable effect You need to reach higher doses (10-15 mg) before seeing consistent results Your optimal maintenance dose trends toward the upper end of the range Conversely, if you weigh less than the trial average, lower doses may produce significant effects, and the maximum dose may not be necessary or desirable

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[Abstract]2021 Oct;22(4):711

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MC4R is expressed in hypothalamus, cortex, hippocampus, and striatum