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No adverse events associated with LC administration were recorded at a dose 6 g/day for 12 months of supplementation in the patients with acute anterior myocardial infarction [87], or at a dose 1.274 g/day (range 0.33 g/day) and duration 348 days (range 93744 days) in patients with liver cirrhosis [88]

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Moreover, low to moderate hsCRP has been associated with gingivitis and chronic periodontitis, with the latter showing slightly higher values [501,502,503]

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Apart from the complement pathways, the anti-inflammatory properties of CRP may be linked to its ability to enhance the expression of Il-1 receptor antagonist in human peripheral blood mononuclear cells [26]

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