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These proteins exist in three subtypes: SREBP-1a, SREBP-1c, and SREBP-2, each contributing to distinct metabolic pathways ( Peroxisome proliferator-activated receptor-alpha (PPAR-) serves as a pivotal transcription factor that orchestrates the transcriptional regulation of genes containing peroxisome proliferator response elements (PPREs) (Yamazaki et al., 2025)

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Genetically engineered mouse models of pancreatic cancer: the KPC model (LSLKrasG12D/+