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Together with six homologs of the cytochrome subunit of NADPH oxidaseNOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2it constitutes the NOX enzyme family

NOX4 is expressed strongly in the kidney and is present in all vascular cells, fibroblasts, osteoclasts, and neurons

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[DOI] [PubMed] [Google Scholar] 28.Sauvant C., Holzinger H., Gekle M

If your diet is already high in other sulfur-rich foods (like garlic, onions, and cruciferous vegetables) or common reflux triggers (like spicy foods, caffeine, or alcohol), adding glutathione might be the straw that breaks the camels back.

Is the mechanism of metabolic reprogramming consistent across these diverse cell types