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Description
OCTN2 contains a glucose-transporter signature motif between transmembrane domains 2 and 3 in which substitution of arginine 169 with glutamine, proline or tryptophan (all identified in patients with primary carnitine deficiency) impairs transporter function without impairing maturation to the plasma membrane [95]

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Without adequate ATP, neurons cannot maintain their resting membrane potentials, fire action potentials efficiently, or synthesize the neurotransmitters required for memory, focus, and emotional regulation

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2022;63(2 Suppl 3):E23945
