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Endothelial dysfunction (ED) is the earliest detectable functional disturbance in the natural history of the disease and a powerful predictor of future CV events [9]

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Hypoxia promotes GSH synthesis in seal cells High tissue and circulating GSH levels, as well as high activity of many glutathione-dependent antioxidant enzymes, including glutathione peroxidases (GPX) and glutathione S -transferases (GST) [18, 20,21,22, 63], suggest a critical role for GSH in protecting diving mammals against oxidative stress

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Han S, Yang X, Zhuang J, Zhou Q, Wang J, Ru L, et al