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Some studies suggest that B12 can increase the production of certain compounds that irritate the skin, especially on the face and back

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Self-Administration Training and Protocols For those needing long-term Vitamin B12 injections, self-administration training is often necessary

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Another reported effect has been growth of lymphoid tissue (specially acromegaly and tonsillar hypertrophy), renal enlargement (with normal kidney function) and in rare cases facial coarsening of features and incremented hair growth [264]