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In a prior research, adding LC to Sertoli cell culture medium significantly increased the secretion of pyruvate and lactate, which are essential for energy production and maturation of sperm cells in the testis [72]
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On the other hand, the injection was superior to oral routes that require more time commitment, patient compliance, and expenditure
The mtDNA is more vulnerable to excessive ROS-related damage to biomolecules, such as DNA repair enzyme proteins, than nuclear DNA (112), which disrupts the ETC and ultimately induces dysregulation of mitochondrial OXPHOS (113)
doi: 10.1136/bcr-2023-255319 [PubMed] 37519503 Doar NW, Adhikari S, Aryal B, Edara S, Schmidt M
Importantly, dietary habits often remain unchanged after diagnosis, suggesting that nutritional management is underappreciated in clinical care [174]
