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Tesofensine works by inhibiting the reuptake of serotonin, noradrenaline, and dopamine

Prescription and administration: Once B12 deficiency is confirmed, GPs prescribe hydroxocobalamin injections according to standardised protocols: Standard loading regimen: 1mg intramuscularly three times weekly for two weeks Neurological involvement: 1mg intramuscularly on alternate days until no further improvement Maintenance therapy: 1mg every three months for life in pernicious anaemia or malabsorption conditions (or every two months if there was neurological involvement) Injections are typically administered by practice nurses at GP surgeries

5-Amino-1MQ is a small-molecule methylquinolinium derivative, not a peptide

Drinking a lot of alcohol or taking certain medicines can also affect B12 absorption

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Combining compounds with distinct mechanisms requires careful dose titration and physiological monitoring