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In vitro study found that topiramate increased MDA, NO and ROS production in astrocytes, showing a dose-dependent negative effect (Pavone and Cardile, 2003)

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doi: 10.21037/jgo.2018.04.07 [DOI] [PMC free article] [PubMed] [Google Scholar] 240

Consequently, despite the potential for higher initial blood levels, the inherent physiological immaturity and reduced somatic mass associated with preterm birth mean that these infants have significantly diminished endogenous L-carnitine reserves

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