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This work was supported by AMED Grant Number JP21zf0127001 (T.S.), JST, CREST Grant Number JPMJCR2123 (T.S.), MEXT KAKENHI Grant Number JP23H04946(T.S.) and World Premier International Research Center Initiative (WPI), Human Biology-Microbiome-Quantum Research Center (Bio2Q) (T.S.), MEXT, Japan

( a ) Scheme for investigating liver cysteine, cholesterol, total triglycerides (TG), and bile acid levels in response to liver-specific LRRC58 KD in vivo

They interact with neurexins (NRXNs) on the presynaptic cell surface to regulate synaptic differentiation, thereby contributing to the formation of either inhibitory or excitatory synapses ( Among the NLGN isoforms, NLGN1 is predominantly involved in excitatory synapse structure, transmission, and plasticity, but has minimal effects on inhibitory synapses.While its direct link to ASD remains unclear, alterations in NLGN1 expression may contribute to cognitive impairments through disruptions in synaptic plasticity and learning-related neural circuits ( In Nlgn2 R215H mutant mice, inhibitory synaptic transmission is significantly reduced in the prefrontal cortex, accompanied by decreased levels of the GABAA receptor 2 subunit and vesicular transporters

1 However, EGT content in mushrooms varies widely among species

It helps reduce stress caused by reactive oxygen species which can cause damage to cellular structures and metabolic processes