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GLS1 is overexpressed in various cancer cells, and this phenotype is associated with a higher disease stage and a poor prognosis 10

Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice

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Its primary physiological function is to elevate intracellular glutathione concentrations in all major organs

All animal studies were conducted with the approval of the ethics committee of USTC

Abstract Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and glutathione (GSH) depletion and represents a therapeutic vulnerability in hepatocellular carcinoma (HCC)