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As different type of ECM remodeling enzymes, they degrade ECM and open the migration track for cancer cells
(PubMed) West AL, Oren GA, Moroi SE
Brain (2021) 144(8):240115
Although melanoma represents one of the most immunogenic tumors, which could have elicited adaptive antitumor immune response due to its high mutational burden, 464 yet plasticity of melanoma allows it to evade the immunosurveillance of the immune system
Bisphosphonates promote the expression of the osteogenic genes alkaline phosphatase (ALP) , bone morphogenetic protein-2 (BMP-2) and osteocalcin (OC) in marrow mesenchymal stem cells (MSCs) (Ribeiro et al., 2014) and directly enhance osteoblast formation and subsequent mineral deposition, which may be another mechanism by which they exert anti-osteoporosis (Lindtner et al., 2014)
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